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This skin model revealed favorable biological characteristics that included a stabilized fibroblast-stretched dermis and stratified epidermis layers after 14 days. Our transwell system indicates a supportive 3D construct composed of PCL, enabling the maturation of a skin model without the aid of commercial transwell inserts. Following this process, keratinocytes were uniformly distributed onto the engineered dermis by the inkjet module. Taking these features together, we engineered a human skin model with a functional transwell system the transwell system and fibroblast-populated dermis were consecutively fabricated by using the extrusion modules. We began by revealing the significance of each module in engineering human skin models by using the extrusion-dispensing module, we engineered a collagen-based construct with polycaprolactone (PCL) mesh that prevented the contraction of collagen during tissue maturation the inkjet-based dispensing module was used to uniformly distribute keratinocytes. A hybrid 3D cell-printing system was developed, allowing for the use of extrusion and inkjet modules at the same time. The paper’s abstract reads, “In this paper, we present a new 3D cell-printing strategy for engineering a 3D human skin model with a functional transwell system in a single-step process.
The POSTECH team recently published their work on the breakthrough process in a research paper, titled “ Direct 3D cell-printing of human skin with functional transwell system,” in the Biofabrication journal co-authors include Byoung Soo-Kim, Ge Gao, Jung-Seob Lee, and lead author Dong-Woo Cho, who was also part of a team in 2014 that developed a 3D printed scaffolding implant that was used to help realign a patient’s eyes after a tumor removal. A research team from Pohang University of Science and Technology (POSTECH) in South Korea, no stranger to 3D printing research, has just introduced an innovative single-step process for 3D bioprinting synthetic skin. Bioengineers have been looking into different 3D printing techniques to produce synthetic human skin for years, as it could also help with reconstructive surgery. There has been a lot of research into 3D printed skin, which is great news for burn victims, those suffering from skin disease, and those who want to hold on to to their youth. While the largest internal human organ is the liver, by now we should all know that the skin is the actual largest organ. I remember teachers asking the question, “What is the largest human organ?” in class many years ago, and most kids shouted out incorrect guesses, like the stomach or the brain.
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